Seeking Patients for Research

Current Studdies:


Fragile X Study

Genes contain instructions that tell our bodies how to develop and function properly. In this study we are testing blood samples for a specific gene variant (called “fragile X premutation”) that may indicate an increased chance for developing ovarian dysfunction that increases the chance of having an early menopause and, potentially, infertility. The purpose of this study is to find out how common this gene is in women with certain fertility problems compared to women with premature menopause, to learn how the gene might be related to the woman’s age at infertility, and to learn the range of emotional reactions to this genetic screening test. This research is being conducted in cooperation with the University of Virginia. Participation is limited to women with certain infertility-related ovarian conditions. If you have ever been diagnosed with diminished ovarian reserve or have had a follicle-stimulating hormone level that was elevated, we welcome you to contact Dr. Steve Young at 919-966-5283 or youngs@med.unc.edu.

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Normal Endometrium Study

This is an ongoing project that is a key element of our ongoing research on the endometrium, or the tissue that lines the uterus. The endometrium changes throughout the menstrual cycle, and is where the embryo attaches and implants in the womb. We seek healthy women with no known fertility issues who also meet the following criteria:

Subjects would have an initial appointment to review the consent form and possibly also receive ovulation test kits to use at home. A second visit for the study procedure is scheduled for a specific time in your menstrual cycle and typically takes no more than one hour. Those who complete this study receive $200. For more details please contact Dr. Steve Young at 919-966-5283 or youngs@med.unc.edu.

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Progesterone Study

When a woman gets pregnant, there is a crucial time when the new embryo attaches to the endometrum, the tissue lining the inner wall of the uterus. The time when this occurs is called the window of implantation and successful pregnancy depends on it. This exciting project is part of an ongoing series of studies that uses a unique model of infertility in healthy women. By using a medication to safely prevent volunteers from ovulating for one menstrual cycle, our physicians can then control the levels of estrogen and progesterone during the time implantation would occur. This model has allowed our doctors to gain insight into the regulation of implantation and how small changes in estrogen or progesterone at that crucial time might influence implantation. This study takes 7-8 weeks to complete, 8 visits total. The basic requirements include:

Subjects have an initial appointment to review the consent form and to receive ovulation test kits for use at home. Most visits take less than an hour, and you’re your parking costs are covered. Those who complete this study receive $400 and it may also be completed together with the Normal Endometrium Study.  For more details please contact Dr. Steve Young at 919-966-5283 or youngs@med.unc.edu.

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